Folding of b-lactoglobulin : nonhierarchic or hierarchic?
نویسندگان
چکیده
منابع مشابه
Is protein folding hierarchic ? I . Local structure and peptide folding
ALTHOUGH SYNTHETIC ANALOGS of proteins might be developed ultimately, Flory’s succinct statement accurately summarizes the remarkable behavior of globular proteins. Today, an intense search is being made for the principles that guide the folding process. Although the work began with experimental studies (see Box 1), it has become increasingly clear that these results cannot be interpreted succe...
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The folding reactions of some small proteins show clear evidence of a hierarchic process, whereas others, lacking detectable intermediates, do not. Evidence from folding intermediates and transition states suggests that folding begins locally, and that the formation of native secondary structure precedes the formation of tertiary interactions, not the reverse. Some notable examples in the liter...
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A number of proteins are (partially) unstructured at physiological conditions and assume a well-defined three-dimensional structure only upon binding to another protein or macromolecular complex. Numerous examples have been found especially among proteins involved in regulatory functions in eukaryotic cells. Recent computer simulations by Verkhivker et al. have yielded an atomic detail picture ...
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We analyze the contracting structure in a moral hazard setting with several agents where output is produced jointly and is the only contractible variable. Since the salary of each agent is a function of all agents efforts, a positive externality arises between them. This externality is not internalised by a centralised structure where the principal contracts directly with each agent. Instead, w...
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The density matrix formalism which is widely used in the theory of measurements , quantum computing, quantum description of chemical and biological systems always imply the averaging over the states of the environment. In practice this is impossible because the environment U\S of the system S is the complement of this system to the whole Universe and contains infinitely many degrees of freedom....
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2001
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.41.s12_1